The Knicks’ first loss in six games could prove doubly costly.

LeBron James recorded a triple-double Saturday night in what potentially could be his final career game at Madison Square Garden, and the Knicks couldn’t overcome an injury to two-way forward OG Anunoby as their five-game winning streak came to an end with a 128-112 loss to the Lakers.

“We gave up like 130 points, that was disappointing,” Josh Hart said. “We weren’t connected enough on defense. We were stagnant offensively. In this win streak, our defense created a lot of our offense. … But I don’t think we did that today.”

LeBron James, who had 33 points, 12 assists and 11 rebounds, slams home a dunk during

the Knicks’ 128-112 loss to the Lakers on Feb. 1, 2025. Jason Szenes for New York Post

The defeat was exacerbated by Anunoby suffering a noncontact injury and limping to the locker room with what the Knicks later termed a sprained right foot after he dropped to one knee upon receiving a pass on the perimeter 1:22 into the third quarter.

Tom Thibodeau said X-rays came back negative, but the Knicks struggled while Anunoby missed significant time last season with an elbow issue and again in the playoffs when he injured his hamstring.

“Obviously praying for the best, but I know as much as you guys do right now,” Jalen Brunson said. “Obviously he’s huge for our team. It’s always tough to see something like that.”

The 40-year-old James registered his 122nd career triple-double with 33 points, 12 assists and 11 rebounds for the Lakers, who reportedly pulled off a blockbuster trade to import star Luka Doncic in a deal sending center Anthony Davis — who didn’t play Saturday night — and a first-round pick to Dallas.

The Lakers shot 47.5 percent (19-for-40) from 3-point range, and LeBron’s son, rookie Bronny James, even made his MSG debut and scored late in the game after the crowd was chanting his name.

OG Anunoby goes down with a right foot sprain while looking to make a move on LeBron James during

the third quarter of the Knicks’ loss to the Lakers. Fireside Knicks / X

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“It’s unbelievable. He’s about to be 41, and I think the game shouldn’t take those guys for granted,” Hart said about LeBron. “Obviously, he’s talking about the end, Steph [Curry], KD [Kevin Durant], all those elder statesmen, but they’re all playing at a high level this late in their careers. It just speaks to their work ethic, and the game and the fans shouldn’t take them for granted.”

Hart had 26 points, 13 rebounds and 11 against the team that drafted him in 2017 to notch his seventh triple-double of the season.

But leading scorers Brunson (17 points) and Karl-Anthony Towns (11) combined to shoot 10-for-30 from the floor for the Knicks (32-17).

LeBron James drives between OG Anunoby (left) and Karl-Anthony Towns during the Knicks’ loss to the Lakers. Jason Szenes for New York Post

James’ teams now have posted a 24-9 record in 33 career games at the Garden in the regular season in his 22-year NBA career.

He also played in one playoff series against the Knicks in 2012 with the Heat.

After receiving a respectful ovation during pregame warmups, the NBA’s all-time leading scorer got to the rim right away and scored the first points of the game. James finished the period with 13 points, and the Lakers took a 59-54 edge into halftime.

LeBron James looks to make a pass over Mikal Bridges during the Knicks’ loss to the Lakers. Jason Szenes for New York Post

After Anunoby departed early in the third, the Lakers pushed their cushion to nine on three free throws by Austin Reaves (27 points).

Hart recorded his 10th assist with a bounce pass to Achiuwa for a dunk and buried a 30-footer at the buzzer to pull the Knicks within 91-89 entering the final period.

But the Lakers opened the fourth on a 13-4 spurt, and Gabe Vincent’s second 3-pointer of the quarter gave them 109-97 advantage with 8:10 remaining.

Karl-Anthony Towns argues after being called for an offensive foul during the Knicks’ loss to the Lakers. Brad Penner-Imagn Images

Hart’s transition dunk off a steal cut the deficit to seven just past the midpoint, but James sank another 3-pointer to get the Lakers’ lead back to double digits.

The Knicks previously had posted strong wins over the Kings, Grizzlies and Nuggets, with the Rockets coming in on Monday.

The Knicks’ remaining strength of schedule entering the game was the highest in the Eastern Conference with an opponents’ combined winning percentage of .526 over the final 34 games, and tied for fourth-hardest overall in the league, according to Tankathon.

“We’ve been playing well, so we’re not going to let this one loss knock us down to rock bottom,” Hart said. “We just gotta make sure we regroup and be ready for Houston.”