MSNBC said on Monday that Jen Psaki, the former White House press secretary who has become one of the most prominent hosts at the network, would anchor a nightly weekday show in prime time.

Ms. Psaki, 46, will host a show at 9 p.m. Tuesday through Friday, replacing Alex Wagner, a longtime political journalist who has anchored that hour since 2022, according to a memo to staff from Rebecca Kutler, MSNBC’s president. Ms. Wagner will remain at MSNBC as an on-air correspondent.

Rachel Maddow, MSNBC’s biggest star, has been anchoring the 9 p.m. hour on weeknights for the early days of President Trump’s administration but will return to hosting one night a week at the end of April.

MSNBC has been planning to overhaul its schedule for weeks. The network is canceling the 7 p.m. program anchored by Joy Reid, who has anchored that time-slot since 2020. On Monday the network said Ms. Reid would be replaced at 7 p.m. by three hosts: Symone Sanders Townsend, a political commentator and former Democratic strategist; Michael Steele, a former chairman of the Republican National Committee; and Alicia Menendez, an anchor on the network.

Ms. Reid is leaving the network, Ms. Kutler said in her memo. The three replacing her currently co-host “The Weekend,” which airs Saturday and Sunday mornings.

Ms. Reid said in a statement that she was proud of the work she and her team accomplished during her time at MSNBC, including coverage of Kamala Harris’s campaign for president, interviewing Brittney Griner on her ordeal in Russia and covering the police killings of Black Americans.

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