Xavier vs St. John’s Predictions, Odds, Time: 2025 College Basketball Picks

The Xavier Musketeers take on the St. John’s Red Storm in New York, NY. Tip-off is set for 7 p.m. ET on FS1.

St. John’s is favored by 7.5 points on the spread with a moneyline of -350. The total is set at 150 points.

Here are my Xavier vs. St. John’s predictions and college basketball picks for January 22, 2025.

Xavier vs St. John’s Prediction

My Pick: St. John’s -7.5 or Better

My Xavier vs St. John’s best bet is on the Red Storm spread, with the best odds currently available at BetRivers. For all of your college basketball bets, be sure to find the best lines by using our live NCAAB odds page.

Xavier vs St. John’s Odds, Spread, Pick

Wednesday, Jan. 22

7 p.m. ET

FS1

Xavier OddsSpreadTotalMoneyline+7.5

-110

150

-110 / -110

+275

St. John’s OddsSpreadTotalMoneyline-7.5

-110

150

-110 / -110

-350

  • Xavier vs St. John’s spread: St. John’s -7.5
  • Xavier vs St. John’s over/under: 150 points
  • Xavier vs St. John’s moneyline: St. John’s -350, Xavier +275
  • Xavier vs St. John’s best bet: St. John’s -7.5 or Better

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My Xavier vs St. John’s College Basketball Betting Preview

Xavier had a fantastic week last week, pulling out three straight wins over DePaul, Villanova and Marquette (on the road) to crawl back to 4-4 in conference play.

But I wonder if that success is sustainable heading on the road again against Rick Pitino’s Johnnies, who have soared to the top of the Big East standings at 7-1 after five straight wins — including a 10-point road victory at Xavier.

In that matchup, the Red Storm owned the boards, winning the rebounding battle 50-30, which included 20 offensive rebounds that led to 22 second-chance points. They also won the turnover battle 12-8 and generated 14 fast-break points.

So, while the Johnnies didn’t shoot well (49% from 2, 13% from 3) and were mostly less efficient than Xavier, they won the shot-volume battle by 21, and that’s an impossible margin to overcome.

The schematic matchup almost doesn’t matter when you get out-athlete’d by that much, as the Red Storm jumped out to an early lead and never looked back.

It’s tough to see the Musketeers flipping the script in the shot-volume battle, especially with the rematch coming in Jamaica. That’s especially true in a letdown spot after pulling off a killer outright road win as a double-digit ‘dog.

Our Action PRO Model projects the Red Storm as an 8.5-point home favorite on Wednesday, so I think there’s some value on St. John’s laying seven or fewer.

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